RESEARCH ARTICLE


Human Basophil Phenotypes and the Associated Signaling Mechanisms



Donald MacGlashan, Jr.*
Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224.

Article Information


Identifiers and Pagination:

Year: 2010
Volume: 3
First Page: 60
Last Page: 72
Publisher Id: TOALLJ-3-60
DOI: 10.2174/1874838401003010060

Article History:

Received Date: 14/2/2010
Revision Received Date: 7/5/2010
Acceptance Date: 12/5/2010
Electronic publication date: 26/11/2010
Collection year: 2010

© 2010 Donald MacGlashan;

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224; Tel: 410-550-2145; Fax: 410-550-2130;E-mail: dmacglas@jhmi.edu


Abstract

A variety of studies have shown that human basophils are participants in allergic reactions and a recent study has indicated that it may even be important in the immediate reaction generally associated with a mast cell response. Therefore, it is important to understand how the function of these cells is regulated and whether the functionality has a relationship to the presence and severity of diseases like atopy. There are many indications that for IgE-mediated secretion, the regulation of syk expression is relevant to the broad distribution of outcomes observed in the general population. The factors influencing the expression of syk will be explored. In addition the outcomes of studies surveying signal element expression by various methods will be discussed.

Keywords: Signal transduction, syk, SHIP, FcεRI, CD34-progenitors.